Platelet-Rich Fibrin (PRF)
Your Body’s Healing Power, Reimagined for Skin Health
At Radiance Wellness in San Diego near Hillcrest and Bankers Hill, we believe the most effective skin rejuvenation treatments come from within. Platelet-Rich Fibrin (PRF) is a cutting-edge regenerative therapy that uses your own blood—specifically, your platelets, white blood cells, and a fibrin matrix—to stimulate collagen production, improve skin texture, and accelerate the natural healing process.¹
PRF is often compared to Platelet-Rich Plasma (PRP), but here’s the difference: PRF contains a fibrin scaffold that allows for a slower release of growth factors, extending and enhancing the benefits for your skin, hair, and overall wellness.²
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Whether used alone or paired with treatments like microneedling, BOTOX®, or laser, PRF offers a holistic, biologically compatible approach to skin rejuvenation—with long-lasting results and no synthetic additives.
At Radiance Wellness, our PRF treatments are performed by experienced medical providers and tailored to your aesthetic goals:
1. Microneedling with PRF
Combines the collagen-boosting benefits of microneedling with PRF’s potent growth factors. PRF is delivered directly through microchannels to enhance healing, improve skin texture, minimize acne scars, and address pigmentation.
- Best for: Melasma, acne scars, pigmentation, fine lines, signs of aging.
- Treatment plan: 3–6 sessions, 4–6 weeks apart; for age management, 4–6 sessions every 12 weeks.
2. PRF EZ Gel
A 100% natural alternative to dermal filler, PRF EZ Gel transforms your own blood into a gel-like consistency for subtle facial rejuvenation. Ideal for the under-eye area, dark circles, and restoring volume in the temples, nasolabial folds, cheeks, and jawline.
- Best for: Patients not suited for traditional fillers or who prefer natural enhancement.
- Treatment plan: 3 sessions, 4–6 weeks apart; yearly maintenance for optimal results.
3. PRF Injections
Targeted PRF injections for areas like the under-eyes, neck, and décolleté to improve elasticity, refine texture, and support collagen and elastin production—without adding volume.
- Treatment plan: 3 sessions, 4–6 weeks apart; yearly maintenance.
4. PRF for Hair Restoration
PRF hair restoration uses your body’s own regenerative growth factors to awaken dormant follicles, encourage new growth, and reduce hair shedding—naturally. It’s an excellent option for those experiencing early to moderate androgenetic hair loss (male or female pattern thinning), stress-related shedding, or post-partum hair loss. Because PRF works with your body’s natural healing process, it helps improve hair density and scalp health over time.
- Treatment plan: 3 sessions spaced 4-6 weeks apart, then a 4-month booster with yearly maintenance.
PRF at a Glance
Once prepared, PRF is applied or injected into your treatment areas. This stimulates stem cells, collagen, and elastin production, triggering skin rejuvenation and tissue regeneration from the inside out.
Because PRF is derived entirely from your own biology, the risk of allergic reactions is extremely low. Over the following weeks, your skin becomes smoother, firmer, and more radiant—without looking overdone.
How PRF Works: Regeneration from the Inside Out
Benefits of PRF
- Improves skin tone, texture, and firmness³
- Smooths fine lines and early wrinkles
- Brightens and thickens under-eye skin
- Minimizes acne scars and enlarged pores
- Supports healing after microneedling or laser
- Stimulates hair growth and improves hair density
- Provides natural anti-aging results
What to Expect
Because PRF is created from your own blood, the quality of that blood directly impacts your results. In the days leading up to your appointment:
- Avoid blood-thinning medications or supplements for at least 48 hours (only if cleared by your physician)
- Avoid alcohol for 48 hours
- Stay well-hydrated by drinking plenty of water
- Follow a healthy, low-fat diet to support optimal platelet quality
These simple steps help ensure your PRF contains the highest concentration of platelets, growth factors, and healing components for the best possible outcome.
Treatment
A small blood draw is performed. The sample is spun in a medical-grade centrifuge to create your PRF. Depending on your chosen therapy—PRF injections, PRF EZ Gel, or microneedling with PRF—a numbing cream may be applied for comfort.
Recovery Time & Aftercare
Downtime is minimal. You may experience mild swelling, redness, or tenderness, which resolves quickly. Your provider will give you tailored aftercare to protect your results.
Why Choose Radiance Wellness for PRF Therapy?
- Use advanced centrifuge technology for superior PRF concentration
- Customize each plan for your skin and hair needs
- Integrate PRF with other med spa treatments for enhanced outcomes
- Provide honest guidance in a warm, non-judgmental environment
FAQs
How is PRF different from PRP?
Both platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) come from your own blood and use your body’s growth factors to stimulate collagen production and healing. PRF is spun in the centrifuge at a lower speed, which preserves more white blood cells and a fibrin matrix. This allows for a slower, sustained release of growth factors, extending the benefits for skin rejuvenation and hair restoration.
Is PRF safe?
Yes. Because PRF is made entirely from your own biology—with no synthetic additives—the risk of allergic reactions is extremely low. This makes it a safe, natural option for most people seeking facial rejuvenation or hair growth treatments.
How many PRF treatments will I need?
The number of sessions depends on your chosen PRF therapy and your aesthetic goals. Most patients benefit from a series of 2–6 sessions, followed by yearly maintenance for long-lasting results. For hair restoration, we recommend 3 sessions spaced 4-6 weeks apart, then a 4-month booster with yearly maintenance.
Discomfort is generally minimal. We use topical numbing and gentle injection techniques to ensure your comfort. Most patients describe the experience as very tolerable, with only mild pressure or a pinch during treatment.
What can PRF treat?
PRF is versatile and can improve skin texture, smooth fine lines, reduce dark circles under the eyes, minimize acne scars, stimulate hair growth, and even add subtle volume with EZ Gel.
Does PRF hurt?
We use numbing cream before most PRF treatments to keep you comfortable. You may feel light pressure or a quick pinch during PRF injections, but most patients describe it as very tolerable.
What is the recovery time?
Downtime is minimal. You might experience mild redness, swelling, or tenderness in the treatment area for 1–2 days. Aftercare guidelines—like avoiding strenuous activity, makeup, or saunas for the first 24–48 hours—help ensure optimal results.
Can I combine PRF with other treatments?
Absolutely. PRF enhances the effects of microneedling, laser treatments, BOTOX®, and injectables by supporting healing and amplifying collagen production. Your provider will help design a treatment plan that combines modalities for your unique skin or hair goals.
¹ Dermatologic Therapy. Platelet-Rich Fibrin as an Effective Method of Skin Revitalization. https://onlinelibrary.wiley.com/doi/10.1155/2023/9040608. Accessed August 14, 2025.
² Indian Dermatology Online Journal. Platelet-Rich Fibrin, Preparation and Use in Dermatology. https://pmc.ncbi.nlm.nih.gov/articles/PMC8664174/. Accessed August 14, 2025.
³ Dermatology Practical and Conceptual. Evaluation of the Effect of Platelet-Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial. https://pmc.ncbi.nlm.nih.gov/articles/PMC9946120/. Accessed August 14, 2025.
How much does a PRF treatment cost?
Pricing varies based on your personalized treatment plan. During your consultation, our team will help determine the best approach for your goals.
For the most current pricing, visit our Service Menu or schedule a consultation at Radiance Wellness.
PRF EZ Gel Injectable Instructions
Pre-care
- Schedule your appointment at least 2 weeks before any special event, as swelling or bruising may occur.
- Avoid blood-thinning agents for 3–7 days before and after treatment, including aspirin, NSAIDs (ibuprofen, naproxen), fish oil, flaxseed oil, vitamin E, vitamin A, ginkgo biloba, garlic, turmeric, and St. John’s Wort. Always consult your physician before stopping any prescribed medications.
- Avoid alcohol, caffeine, and nicotine (including vaping) for 48–72 hours before and after treatment to support optimal circulation and healing.
- Hydrate thoroughly for 48–72 hours before your appointment by drinking at least 64 oz (about 2 L) of water daily to enhance blood quality and platelet yield.
- Eat a healthy, low-fat, nutrient-rich diet with foods high in iron, vitamin C, zinc, and antioxidants to support healing and collagen production.
- Consider taking oral Arnica montana 2 days before treatment to help minimize bruising.
- Treatment cannot be performed over active acne, rashes, or skin infections in the treatment area.
- Discontinue laser treatments, IPL, waxing, microneedling, and chemical peels in the treatment area for at least 7 days before your appointment.
- You may not be pregnant. If you are breastfeeding, written clearance from your OB-GYN is required.
Your Appointment
- A topical anesthetic may be applied to keep you comfortable.
- A small sample of your blood will be drawn and processed into EZ PRF Gel—a natural, bio-stimulating filler made from your own platelets and plasma.
- EZ Gel will be injected using a fine needle or cannula into areas of volume loss such as the cheeks, tear troughs, nasolabial folds, temples, or jawline.
- Gentle massage may be used during treatment to distribute the gel evenly.
- Results develop gradually over 4–8 weeks as your body regenerates collagen. A series of 2–3 treatments spaced 4–6 weeks apart is typically recommended, with maintenance every 6–12 months.
Post-care
- Swelling is normal and expected due to purposeful overfilling. It is a good sign that your body is initiating regeneration.
- Avoid applying ice or pressure to the treated area for at least 48 hours, as this may interfere with product integration.
- Redness, tenderness, minor bruising, or small lumps at injection sites are common and should resolve within 3–10 days.
- Do not massage, rub, or sleep on your face the first few nights. Sleep on your back with your head slightly elevated to minimize swelling.
- Avoid strenuous activity, excessive sweating, saunas, hot tubs, and prolonged sun or heat exposure for 24–48 hours after treatment.
- Do not apply makeup for 24 hours after your treatment to reduce the risk of infection.
- Use Tylenol (acetaminophen) only if needed for discomfort. Avoid NSAIDs such as ibuprofen or aspirin unless directed by your provider.
- Continue staying well-hydrated and eating nutrient-dense foods to support healing and collagen stimulation.
- Avoid cosmetic treatments in the treated area—including facials, microneedling, lasers, and peels—for 2 weeks.
- Contact your provider if you experience increased or persistent swelling, pain, redness, warmth, fever, or other signs of infection.
PRF Hair Restoration Instructions
Pre-care
- Schedule your appointment at least 2 weeks before any special events, as redness, swelling, or bruising may occur.
- Avoid blood-thinning agents for 3–7 days before and after treatment unless prescribed by your physician. This includes aspirin, NSAIDs (ibuprofen, naproxen), fish oil, flaxseed oil, vitamin E, vitamin A, ginkgo biloba, garlic, turmeric, and St. John’s Wort.
- Avoid alcohol, caffeine, nicotine (including vaping), and niacin supplements for 48–72 hours before and after treatment to support optimal healing and platelet function.
- Hydrate well for 48–72 hours before your appointment, drinking at least 64 oz of water daily to improve blood quality.
- Eat a healthy, low-fat, nutrient-dense diet in the days leading up to your appointment. Focus on foods rich in iron, zinc, vitamin C, vitamin D, and biotin to support follicle health.
- Consider starting oral Arnica montana supplements 2 days before treatment to minimize bruising.
- Treatment cannot be performed over areas with active scalp infections, rashes, psoriasis, eczema, or acne flares.
- You may not be pregnant. If you are breastfeeding, clearance from your OB-GYN is required.
- Wash your hair the morning of your appointment using a gentle, sulfate-free shampoo. Arrive with clean, dry, product-free hair.
Your Appointment
- A small amount of your blood will be drawn and processed in a centrifuge to isolate platelet-rich fibrin (PRF), also known as your body’s own “liquid gold.”
- PRF will be injected, microneedled, or stamped into areas of thinning or hair loss to stimulate follicles and promote natural regrowth.
- Any remaining PRF will be gently massaged into your scalp to enhance healing and absorption.
- For best results, we recommend a series of 3–4 treatments spaced 4–6 weeks apart, followed by maintenance sessions every 6–12 months.
Post-care
- Redness, swelling, tenderness, and pinpoint bruising are common and usually resolve within a few days.
- Use Tylenol (acetaminophen) if needed for discomfort. Avoid NSAIDs (ibuprofen, aspirin, naproxen) for 3–7 days after treatment, as they may interfere with PRF’s regenerative effects.
- Do not wash your hair or get your scalp wet for 12–24 hours following treatment.
- Avoid strenuous exercise, sweating, saunas, steam rooms, and hot showers for 24–48 hours.
- Do not wear hats, helmets, or tight hairstyles for the first 24 hours.
- Avoid hair dye, chemical treatments, and styling products for 5–7 days after your session.
- Sleep on your back with your head slightly elevated the first night to help reduce swelling.
- Stay well-hydrated and maintain a nutrient-rich diet including vitamin C, vitamin D, zinc, biotin, and iron to support hair growth and healing.
- Contact your provider if you experience prolonged discomfort, signs of infection, or any unusual symptoms.
PRF Injectable Instructions
Pre-care
- Schedule your appointment at least 2 weeks before any special event, as swelling or bruising may occur.
- Avoid blood-thinning agents for 3–7 days before and after treatment, including aspirin, NSAIDs (ibuprofen, naproxen), fish oil, flaxseed oil, vitamin E, vitamin A, ginkgo biloba, garlic, turmeric, and St. John’s Wort. Always consult your physician before stopping any prescribed medications.
- Avoid alcohol, caffeine, and nicotine (including vaping) for 48–72 hours before and after treatment to support optimal circulation and healing.
- Hydrate thoroughly for 48–72 hours before your appointment by drinking at least 64 oz (about 2 L) of water daily to enhance blood quality and platelet yield.
- Eat a healthy, low-fat, nutrient-rich diet with foods high in iron, vitamin C, zinc, and antioxidants to support healing and collagen production.
- Consider taking oral Arnica montana 2 days before treatment to help minimize bruising.
- Treatment cannot be performed over active acne, rashes, or skin infections in the treatment area.
- Discontinue laser treatments, IPL, waxing, microneedling, and chemical peels in the treatment area for at least 7 days before your appointment.
- You may not be pregnant. If you are breastfeeding, written clearance from your OB-GYN is required.
Your Appointment
- We’ll apply topical numbing cream to ensure you’re comfortable during your treatment.
- We’ll draw a small amount of blood (don’t worry — we’re quick!) so we can spin it down and isolate your platelet-rich plasma, aka “liquid gold.”
- Next, we’ll microneedle, stamp or inject your PRF just beneath the skin to boost collagen, elastin and even encourage hair growth.
- We’ll massage any remaining PRF onto your skin so you can reap all the restorative benefits of your body’s healing abilities.
Post-care
- Swelling is normal and expected due to purposeful overfilling. It is a good sign that your body is initiating regeneration.
- Avoid applying ice or pressure to the treated area for at least 48 hours, as this may interfere with product integration.
- Redness, tenderness, minor bruising, or small lumps at injection sites are common and should resolve within 3–10 days.
- Do not massage, rub, or sleep on your face the first few nights. Sleep on your back with your head slightly elevated to minimize swelling.
- Avoid strenuous activity, excessive sweating, saunas, hot tubs, and prolonged sun or heat exposure for 24–48 hours after treatment.
- Do not apply makeup for 24 hours after your treatment to reduce the risk of infection.
- Use Tylenol (acetaminophen) only if needed for discomfort. Avoid NSAIDs such as ibuprofen or aspirin unless directed by your provider.
- Continue staying well-hydrated and eating nutrient-dense foods to support healing and collagen stimulation.
- Avoid cosmetic treatments in the treated area—including facials, microneedling, lasers, and peels—for 2 weeks.
- Contact your provider if you experience increased or persistent swelling, pain, redness, warmth, fever, or other signs of infection.
PRF Topical Add-On to Microneedling Instructions
Pre-care
- Drink plenty of water, avoid alcohol, and consume a healthy, low-fat diet for 48 hours before your appointment—this significantly improves blood quality and the effectiveness of your PRF.
- Avoid blood-thinning agents (aspirin, NSAIDs, fish oil, etc.) for 3 days before and after your treatment unless prescribed by your physician.
Your Appointment
- We’ll draw a small amount of blood (don’t worry—we’re quick!) to create your platelet-rich fibrin matrix (PRF), often referred to as your body’s own “liquid gold.”
- PRF will be applied topically during and immediately after your microneedling session to enhance healing, reduce downtime, and boost collagen production.
- If enough PRF is collected, you may be sent home with additional PRF. Please apply it topically within 1 hour of your treatment using clean hands only.
Follow the same post-care instructions as microneedling, with the following additions
- If you received additional PRF to take home, apply it within one hour of treatment using clean hands.
(To be followed alongside standard microneedling instructions)
Follow the same pre-care instructions as microneedling, with the following additions
Post-care
Ready to discover the benefits of PRF?
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Book your consultation at Radiance Wellness in the Banker’s Hill area of San Diego, just next to Hillcrest, and experience natural healing, skin confidence, and results that enhance—never change—what makes you unique.
